Explainer (short version)

Retinoids are chemical compounds that come from vitamin A, we often refer to them as synthetic vitamin A. While many people recognize them as common ingredients in skincare products, they are also found in various “healthy” foods we eat regularly. What is less well-known is their impact on how our bodies perceive sensations such as heat, cold, pain, and irritation. This occurs because retinoids activate two important sensors in our body, known as TRPV1 and TRPA1.

Think of TRPV1 like a heat detector. It responds to stuff like hot temperatures or spicy foods (like chili peppers). TRPA1, on the other hand, reacts to cold and irritating things (like strong smells or chemicals). These sensors are helpful because they warn us about things that might hurt us. But if they’re constantly turned on, it can cause problems in the body.

When these sensors are overstimulated, they keep sending stress signals to the brain. This activates the "fight or flight" mode in our nervous system. While this is fine in short bursts, keeping the nervous system in overdrive for too long can cause inflammation. Over time, this inflammation can go from being helpful (like when your body heals a wound) to harmful, leading to ongoing health problems.

On top of that, too much stress can create something called oxidative stress. This means your body has too many harmful molecules (called free radicals) and not enough antioxidants to fight them off. This imbalance can damage your cells, speed up aging, and create more long-term health issues. Retinoids, if overused, can make this worse by increasing these harmful molecules. See our list of 40 common conditions, diseases, and neurological disorders caused by oxidative stress.

Stress also changes how your body uses energy. A stress hormone called cortisol can throw off how you process sugar, fat, and protein, which can weaken your overall health.

Another problem? When these sensors (TRPV1 and TRPA1) get stuck in overdrive, it can lead to cravings. Your brain starts looking for ways to calm those stress signals. This is why some people may crave comfort food, social media, or even unhealthy habits like smoking or using certain substances. Over time, this can turn into a dependency.

So, what can you do to feel better? A good first step is to reduce retinoids in your routine—whether that’s from skincare or diet. Then, focus on calming your nervous system. Choosing foods that do not contain retinoids, practicing deep breathing, and finding ways to relax can help restore balance in your body.

Taking care of yourself in these ways can lower stress, reduce inflammation, and help your body work the way it’s supposed to.

At Tranquility Foods, we are dedicated to raising awareness about this important information. We encourage you to join us in continuing to learn and empower yourself to take control of your physical and mental well-being.